Posted: 13 November 2023
VivaZome Therapeutics Pty Ltd (“VivaZome”) is presenting three posters at the 6th annual meeting of the Australian and New Zealand Society of Extracellular Vesicles (ANZSEV) being held this week in the Barossa Valley, South Australia. These posters highlight strategies and technologies for extracellular vesicle (EV) purification, customisation and manufacturing:
1. “From Laboratory to “Manufacturing Methods and Challenges in Exosome Purification” (Shambrook et al)
- This poster outlines VivaZome’s current research-scale purification process for EVs and explores options for clinical-scale processing.
- The authors conclude that the isolation process yields EVs that meet classical characterisation criteria, including the correct size range, shape and expression of EV-associated protein markers.
2. “Customisation Strategies and Loading of EVs to Treat Neurological Disease” (Johnston et al):
- The second poster focuses on strategies for customising EVs including surface and luminal EV modifications and the associated advantages and considerations.
- The authors emphasise the importance of confirming effective EV-modification and functionality.
3. “Establishing a Robust Exosome Manufacturing Process for Translational Studies” (Krishna et al):
- The third poster outlines VivaZome’s roadmap for establishing manufacturing and analytical facilities that will support translational studies, addressing pre-clinical, clinical and regulatory requirements.
- The authors emphasise the importance of maintaining EV integrity and functionality including the safety, pharmacokinetic and pharmacodynamic characteristics of the EV product as it is translated into the clinic.
These posters collectively demonstrate VivaZome’s commitment to advancing the field of EV therapeutcs from research-scale processes to potential clinical applications, underscoring the company’s dedication to translating its research into practical and impactful solutions for neurological and other diseases.
Dr David Haylock, Chief Scientific Officer of VivaZome, said: “We are delighted to be presenting this work at the ANZSEV meeting as we strive to develop new customised EV-based approaches to develop impactful treatments for retinal disease and traumatic brain injury with our esteemed collaborators at Australian National University, The University of Queensland, Cytiva and SeerPharma. These posters highlight the strong progress we are making. Presenting at this excellent event provides an opportunity to showcase the company’s advancements, share insights with peers, and contribute to the broader discussion within the Scientific community.”
The ANZSEV Annual Meeting is the major Australasian scientific conference in the field of EVs. It brings together researchers and scientists from Australia and New Zealand along with international visitors and invited speakers. VivaZome is a silver sponsor of the conference.
