Posted: 13th May 2025
A significant advancement in vaccine technology has been made by WEHI scientists, potentially leading to long-lasting vaccines against viruses and enhanced cancer therapies. The study, published in the Journal of Experimental Medicine, utilized a novel approach with mRNA vaccine technology to increase the formation of stem cell-like memory CD8+ T cells, known for their self-renewing capacity and long-term memory.
Vaccines, while highly effective, often rely on antibodies that fade over time, necessitating boosters. This study demonstrated that these specific T cells could provide long-lasting protection, reducing the need for frequent boosters. Associate Professor Joanna Groom highlighted the promise of these cells in overcoming challenges posed by rapidly mutating viruses like influenza and COVID-19.
The team used immunomodulation and mRNA vaccine technology to promote these potent cells in mice. The results were striking, showing the potential to maintain strong and lasting immunity. This approach could also improve cancer outcomes, as indicated by PhD student Benjamin Broomfield, who noted the potential for new cancer immunotherapies.
This breakthrough suggests a future where more diseases are vaccine-preventable and treatable without regular boosters, bringing us closer to long-lasting immunity.
