Head of Translational Biology – Amplia Therapeutics
Posted: 4 April 2022
Closing: 27 April 2022
Amplia Therapeutics is an ASX-listed biotechnology company based in Melbourne, Australia. Our high-performing team is focused on developing small molecule inhibitors of Focal Adhesion Kinase (FAK) for the treatment of cancer and fibrotic diseases – in partnership with some of the most respected researchers and institutes in the world.
Amplia is currently preparing to enter Phase 2 clinical trials for its lead FAK inhibitor AMP945. In animal models of disease, AMP945 is able to both treat and prevent fibrotic diseases, as well as make cancers more responsive to chemotherapy. If successful, AMP945 could be used to treat complex illnesses like pancreatic cancer – and more.
As this product and others in our pipeline are developed, non-clinical studies must be performed to support clinical trials and build a dataset for regulatory submissions and applications for product registration.
The successful applicant will work effectively with product development teams, clinical and scientific experts, external stakeholders (vendors, contractors etc), and other advisors, to support Amplia’s pre-clinical and clinical development work. The role also requires detailed understanding of drug development. Experience in fibrosis or cancer disease models and their biology are required.
We are inviting applicants with excellent communications skills and a focus on teamwork, who are eager to contribute to our Company’s culture of collaboration, openness, respect, and inclusiveness.
Essential Job Functions
Work with Amplia team members to understand cross-functional priorities, timing and project requirements for non-clinical data.
Propose and design experiments that will support Amplia’s aim to both expand its scope of clinical development opportunities and support existing priority areas.
Identify collaborators or contract research organisations to conduct suitable studies to a suitable quality standard.
Perform project management of pharmacological activities to support clinical development of Amplia’s lead molecules.
Maintain an organised system of records to support future regulatory submissions.
Support writing, review, publication, and filing of pharmacology related regulatory documents including those associated with INDs, CTAs, IMPDs, NDAs, and PAIs.
Prepare presentations, plans and documents capturing key project decisions and actions.
Engage constructively with vendors to solve problems and keep colleagues informed of risks.
Attend and contribute to regular team meetings and play an active role in proposing and executing business improvements.
Other relevant duties as reasonably assigned.
Education and Experience
Post graduate degree (PhD or Masters) or equivalent work experience in pharmacology, medical biology or a related field.
Prior experience in a similar role with minimum 5 years’ experience in non-clinical translational research.
Experience in fibrosis or cancer disease models and their biology are required.
Strong understanding of pharmaceutical product development.
Comfortable working in cross-functional, global, virtual project teams.
Excellent interpersonal and organisational skills, with an ability to build constructive relationships with colleagues and external vendors.
Commitment to professionalism, excellent verbal and written communication skills and close attention to detail.
Demonstrated ability to solve problems and identify high priorities.