5 December 2019
Event date: 10 December
Modeling amyotrophic lateral sclerosis (ALS) using patient-derived induced pluripotent stem cells (iPSCs)
Professor Ludo Van Den Bosch (VIB-KU Leuven Center for Brain & Disease Research, Belgium)
Date: Tuesday 10 December
Venue: Ian Potter Auditorium, Kenneth Myer Building, 30 Royal Parade Parkville
Host: Associate Professor Bradley Turner (firstname.lastname@example.org)
More details: For more information on this seminar or upcoming seminars in the series please contact email@example.com.
Professor Ludo Van Den Bosch Bio:
The research of Ludo Van Den Bosch (KU Leuven & VIB, Leuven, Belgium) focuses on the investigation of the causes, mechanisms and treatment options for neurodegenerative diseases. In particular, he studies amyotrophic lateral sclerosis (ALS, Lou Gehrig’s disease) and its relation to frontotemporal dementia, as well as Charcot-Marie-Tooth disease (an axonal peripheral neuropathy).
For his research, he models different aspects of the different diseases using cell culture models, fruit fly, fish, mouse and rat. As the aim of his research is to translate results from these models to treatment strategies, he intensively collaborates with the Neurology department. At present, a lot of energy is invested into the development of patient-derived induced pluripotent stem cell (iPSC) models. These iPSCs can be differentiated into different cell types, including motor neurons, astrocytes, oligodendrocytes and Schwann cells.
Amongst the different phenotypes observed in these cells, defects in axonal transport in the motor neurons are the most robust ones and the aim is to reverse these defects. In the long run, the goal of this research is to create a human-derived ‘neuromuscular circuit on a chip’ to get a better insight into the disease mechanisms underlying the different diseases and to contribute to the development of new therapeutic strategies for these incurable neurodegenerative disorders.