Backed by significant Venture Capital funding, our client is a biotech start-up developing innovative technologies poised to transform the industry’s approach to quality control and longitudinal monitoring of clinical molecular diagnostics. Key to this strategy is the expansion of their widely published platform which focuses on the use of synthetic DNA and RNA ‘spike-in’ controls to increase the accuracy, performance, and quality of genomic data.
Working as a Bioinformatics Specialist*, your key remit will be to develop and implement bioinformatic pipelines and workflows for the analysis, validation, visualisation, and interpretation of NGS data sets. These will include considerations for the design, implementation, and validation of synthetic controls representative of biomarkers that relate to the needs and requirements of customers, and the product development team.
Design and implement bioinformatics pipelines for analysis of synthetic DNA controls and NGS data sets, including quality control, alignment, variant calling, and annotation.
Develop and implement methods for the design of synthetic controls representing biomarkers, such as somatic mutations and copy number alterations in cancer genomes.
Utilize existing bioinformatics tools and develop new algorithms to identify and annotate genomic variants and analyse synthetic DNA controls.
Evaluate the performance of bioinformatics pipelines and algorithms and implement necessary improvements.
Provide software and analytical support to strategic projects.
Stay up-to-date with new bioinformatics tools, databases, and computational methods for NGS data analysis.
Communicate results and findings with internal team members, as well as external clinical researchers and scientists.
PhD in bioinformatics or related discipline, or a Masters Degree with considerable industry working with NGS data sets (ideally in the context of clinical genomics).
Expertise in computational biology, genomics, and bioinformatics with a solid understanding of NGS protocols, statistical methods and analysis of next-generation sequencing data.
Proficiency in analysing NGS data, such as whole-genome sequencing, cancer diagnostics, and transcriptome sequencing and in developing algorithms and bioinformatics pipelines for identifying genomic variations in cancer genomes.
Proficiency in relevant programming languages, such as R and Python, combined with experience with variant calling and annotation tools such as GATK, SAMtools, and Annovar.
Exceptional verbal and written communication skills accompanied by the ability to work both autonomously, and as part of a fast-paced, multidisciplinary team.
Our client is offering a full-time permanent position with flexible working conditions and the opportunity to work alongside the scientists who developed this cutting-edge technology and have since published their work in high-impact journals. The total remuneration package will include an attractive base salary of up to $155k plus superannuation, optional participation in the company ESOP, and other benefits. Ongoing training and development are also offered, as is the opportunity for interstate and international travel. For more information, you can email firstname.lastname@example.org or contact Mark Thomas or Marilyn Jones at 1300 0 MEXEC for a confidential discussion about the role.